International Journal of Gynecology & Obstetrics
Volume 84, Issue 1 , Pages 5-9 , January 2004

Pregnancy outcomes with increased nuchal translucency after routine Down syndrome screening

  • C.-C. Cheng

      Affiliations

    • Prenatal Diagnosis Center, Cathay General Hospital, Taipei, Taiwan
    • Department of Obstetrics/Gynecology, Cathay General Hospital, Taipei, Taiwan
    • Division of MFM/Department of Obstetrics/Gynecology, University of Cincinnati, Cincinnati, OH, USA
    • ,
  • R.O. Bahado-Singh

      Affiliations

    • Division of MFM/Department of Obstetrics/Gynecology, University of Cincinnati, Cincinnati, OH, USA
    • ,
  • S.-C. Chen

      Affiliations

    • Department of Obstetrics/Gynecology, Cathay General Hospital, Taipei, Taiwan
    • ,
  • M.-S. Tsai

      Affiliations

    • Prenatal Diagnosis Center, Cathay General Hospital, Taipei, Taiwan
    • Department of Obstetrics/Gynecology, Cathay General Hospital, Taipei, Taiwan
    • Corresponding Author InformationCorresponding author. Tel.: +886-2-2708-2121x3553; fax: +886-2-8237-0777

Received 10 January 2003 ,Revised 1 May 2003 ,Accepted 7 May 2003.

References 

  1. Pandya PP, Kondylios A, Hilbert L, Snijders RJM, Nicolaides KH. Chromosomal defects and outcome in 1015 fetuses with increased nuchal translucency. Ultrasound Obstet Gynecol. 1995;5:15–19
  2. Snijders RJ, Johnson S, Sebire NJ, Noble PL, Nicolaides KH. First-trimester ultrasound screening for chromosomal defects. Ultrasound Obstet Gynecol. 1996;7:216–226
  3. Snijders RJ, Noble PL, Sebire NJ. UK multicenter project on assessment of risk of trisomy 21 by maternal age and fetal nuchal translucency thickness at 10–14 weeks’ gestation. Fetal Medicine Foundation First Trimester Screening Group. Lancet. 1998;352:343–346
  4. Taipale P, Hiilesmaa V, Salonen R, Ylostalo P. Increased nuchal translucency as a marker for fetal chromosomal defects. N Engl J Med. 1997;337:1654–1658
  5. Reijnders CS, Pauker SP, Benacerraf BR. First trimester isolated fetal nuchal translucency: significance and outcome. J Ultrasound Med. 1997;16:101–105
  6. Brady AF, Pandya PP, Yuksel B, Greenough A, Patton MA, Nicolaides KH. Outcome of chromosomally normal live birth with increased fetal nuchal translucency at 10–14 weeks’ gestation. J Med Genet. 1998;35:222–224
  7. Sauka AP, Snijders RJ, Novakov A, Soares W, Nicolaides KH. Defects and syndromes in chromosomally normal fetuses with increased nuchal translucency thickness at 10–14 weeks of gestation. Ultrasound Obstet Gynecol. 1998;11:391–400
  8. Pajkrt E, Mol BWJ, Bleker OP, Bilardo CM. Pregnancy outcome and nuchal translucency measurements in fetuses with normal karyotype. Prenat Diagn. 1999;19:1104–1108
  9. Von Kaisenberg CS, Brand-Saberi B, Jonat W, Nicolaides KH. Pathophysiology of increased nuchal translucency in chromosomally abnormal fetuses. Prenat Neonat Med. 1999;4:431–440
  10. Chaban FK, Van Slunder P, Los FJ, Wladimiroff JW. Fetal outcome in nuchal translucency with emphasis on normal karyotype. Prenat Diagn. 1996;16:537–541
  11. Van Vugt JMG, Tinemans BWS, Van Zalen-Sprock RM. Outcome and early childhood follow-up of chromosomally normal fetuses with enlarged nuchal translucency at 10–14 weeks’ gestation. Ultrasound Obstet Gynecol. 1998;11:407–409
  12. Bilardo CM, Pajkrt E, de Graaf I, Mol BW, Bleker OP. Outcomes of fetuses with enlarged nuchal translucency and normal karyotype. Ultrasound Obstet Gynecol. 1998;11:401–406
  13. Fukada Y, Yasumizu T, Takizawa M, Amemiya A, Hoshi K. The prognosis of fetuses with transient nuchal translucency in the first and early second trimester. Acta Obstet Gynecol Scand. 1997;76:913–916
  14. Adekunle O, Goppe A, El-Sayed M, Thilaganathan B. Increased first trimester nuchal translucency: pregnancy and infant outcomes after routine screening for Down's syndrome in an unselected antenatal population. Br J Radiol. 1999;72:457–460
  15. Maymon R, Jauniaux E, Cohen O, Dreazen E, Weinraub Z, Herman A. Pregnancy outcome and infant follow-up of fetuses with abnormally increased first trimester nuchal translucency. Hum Reprod. 2000;15:2023–2027
  16. Mavrides E, Cobian-Sanchez F, Tekay A, Moscoso G, Campbell S, Thilaganathan B, et al.  Limitations of using first trimester nuchal translucency measurements in routine screening for major congenital heart defects. Ultrasound Obstet Gynecol. 2001;17:106–111
  17. Maitas A, Huggon I, Areias JC. Cardiac defects in chromosomally normal fetuses with abnormal ductus venosus blood flow at 10–14 weeks. Ultrasound Obstet Gynecol. 1999;14:307–310

PII: S0020-7292(03)00206-6

doi: 10.1016/S0020-7292(03)00206-6

International Journal of Gynecology & Obstetrics
Volume 84, Issue 1 , Pages 5-9 , January 2004

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