International Journal of Gynecology & Obstetrics
Volume 84, Issue 2 , Pages 120-126 , February 2004

Endothelin 1 and leptin in the pathophysiology of intrauterine growth restriction

  • M. Arslan

      Affiliations

    • Department of Obstetrics and Gynecology, Mersin University School of Medicine, Mersin, Turkey
    • Corresponding Author InformationCorresponding author. GMK bulvari, Akkent mah, Denizgulu sitesi B-blok, 523/10, Yenisehir, Mersin, Turkey. Tel.: +90-324-341-2565; fax: +90-324-337-4305
    • ,
  • G. Yazici

      Affiliations

    • Department of Obstetrics and Gynecology, Mersin University School of Medicine, Mersin, Turkey
    • ,
  • A. Erdem

      Affiliations

    • Department of Obstetrics and Gynecology, Mersin University School of Medicine, Mersin, Turkey
    • ,
  • M. Erdem

      Affiliations

    • Department of Obstetrics and Gynecology, Gazi University School of Medicine, Besevler, Ankara, Turkey
    • ,
  • E. Ozturk Arslan

      Affiliations

    • Department of Obstetrics and Gynecology, Erdemli State Hospital, Mersin, Turkey
    • ,
  • O. Himmetoglu

      Affiliations

    • Department of Obstetrics and Gynecology, Gazi University School of Medicine, Besevler, Ankara, Turkey

Received 29 April 2003 ,Revised 30 June 2003 ,Accepted 3 July 2003.

References 

  1. Yanagisawa M, Kurihara H, Kimura S, Goto K, Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;332:411–415
  2. Di Iorio R, Marinoni E, Anceschi MM, Emiliani S, Letizia C, Cosmi EV. Amniotic fluid endothelin-1 levels are increased in pregnancy-induced hypertension and intrauterine growth retardation. Am J Reprod Immunol. 1996;36:260–263
  3. Schiff E, Weiner E, Zalel Y, Shlomo M, Sibai BM, Shalev E. Endothelin-1,2 levels in umbilical vein serum of intra-uterine growth retarded fetuses as detected by cordocentesis. Acta Obstet Gynecol Scand. 1994;73:21–24
  4. Neerhof MG, Silver RK, Caplan MS, Thaete LG. Endothelin-1 induced placental and fetal growth restriction in the rat. J Matern Fetal Med. 1997;6:125–128
  5. Liu YA, Östlund E, Fried G. Endothelin induced contractions in human placental blood vessels are enhanced in intrauterine growth retardation, and modulated by agents that regulate levels of intracellular calcium. Acta Physiol Scand. 1995;155:405–414
  6. Remesar X, Rafecas I, Femandez-Lopez JA, Alemany M. Leptin. Med Res Rev. 1997;17:225–234
  7. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, et al.  Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 1995;269:540–543
  8. Matsuda J, Yokota I, Iida M, Murakami T, Naito E, Ito M, et al.  Serum leptin concentration in cord blood: relationship to birth weight and gender. J Clin Endocrinol Metab. 1997;82:1642–1644
  9. Geary M, Pringle PJ, Persaud M, Wilshin J, Hindhmarsh PJ, Rodeck CH, et al.  Leptin concentrations in maternal serum and cord blood: relationship to maternal anthropometry and fetal growth. Br J Obstet Gynaecol. 1999;106:1054–1060
  10. Cetin I, Morpurgo PS, Radaelli T, Taricco E, Cortelazzi D, Bellotti M, et al.  Fetal plasma leptin concentrations: relationship with different intrauterine growth patterns from 19 weeks to term. Pediatr Res. 2000;48:646–651
  11. Xiong Y, Tanaka H, Richardson JA, Williams SC, Slaughter CA, Nakamura M, et al.  Endothelin-1 stimulates leptin production in adipocytes. J Biol Chem. 2001;276:28471–28477
  12. Quehenberger P, Exner M, Sunder-Plassmann R, Ruzicka K, Bieglmayer C, Endler G, et al.  Leptin induces endothelin-1 in endothelial cells in vitro. Circ Res. 2002;90:711–718
  13. Hadlock FP, Harrist RB, Carpenter RJ, Deter RL, Park SK. Sonographic estimation of fetal weight: the value of femur length in addition to head and abdomen measurements. Radiology. 1984;150:535–540
  14. Hartikainen-Sorri AL, Vulteenaho O, Leppaluoto J, Ruskoaho H. Endothelin in umbilical artery vasospasm. Lancet. 1991;337:619
  15. Erdem A, Erdem M, Himmetoglu O, Yildirim G, Arslan M. Maternal and fetal plasma endothelin levels in intrauterine growth restriction: relation to umbilical artery Doppler flow velocimetry. J Perinatal Med. 2003;31:52–59
  16. Shekhawat PS, Garland JS, Shivpuri C, Mick GJ, Sasidharan P, Petz CJ, et al.  Neonatal cord blood leptin: its relationship to birth weight, body mass index, maternal diabetes, and steroids. Pediatr Res. 1998;43:338–343
  17. Jaquet D, Leger J, Levy-Marchal C, Oury JF, Czernichow P. Ontogeny of leptin in human fetuses and newborns: effect of intrauterine growth retardation on serum leptin concentrations. J Clin Endocrinol Metab. 1998;83:1243–1246
  18. Marchini G, Fried G, Ostlund E, Hagenas L. Plasma leptin in infants: relations to birth weight and weight loss. Pediatrics. 1998;101:429–432
  19. Tamura T, Goldenberg RL, Johnston KE, Cliver SP. Serum leptin concentrations during pregnancy and their relationship to fetal growth. Obstet Gynecol. 1998;91:389–395
  20. Koistinen HA, Koivisto VA, Andersson S, Karonen SL, Kontula K, Oksanen L, et al.  Leptin concentration in cord blood correlates with intrauterine growth. J Clin Endocrinol Metab. 1997;82:3328–3330
  21. McCarthy JF, Misra DN, Roberts JM. Maternal plasma leptin is increased in preeclampsia and positively correlates with fetal cord concentration. Am J Obstet Gynecol. 1999;180:731–736
  22. Mise H, Sagawa N, Matsumoto T, Yura S, Nanno H, Itoh H, et al.  Augmented placental production of leptin in preeclampsia: possible involvement of placental hypoxia. J Clin Endocrinol Metab. 1998;83:3225–3229
  23. Lea RG, Howe D, Hannah LT, Bonneau O, Hunter L, Hoggard N. Placental leptin in normal, diabetic and fetal growth-retarded pregnancies. Mol Hum Reprod. 2000;6:763–769
  24. Vane JR, Anggard EE, Botting RM. Regulatory functions of the vascular endothelium. N Engl J Med. 1990;323:27–36
  25. Heida HS, Gomes-Sanchez CE. Hypoxia increases endothelin release in bovine endothelial cells in culture, but epinephrine, norepinephrine, serotonin and angiotensin II do not. Life Sci. 1990;47:2451–2472

PII: S0020-7292(03)00332-1

doi: 10.1016/S0020-7292(03)00332-1

International Journal of Gynecology & Obstetrics
Volume 84, Issue 2 , Pages 120-126 , February 2004

Article Tools

* Image Usage & Resolution