International Journal of Gynecology & Obstetrics
Volume 85, Issue 3 , Pages 255-258, June 2004

Risk of malignancy index in the preoperative evaluation of pelvic masses

  • B.R. Obeidat

      Affiliations

    • Department of Obstetrics and Gynecology, Jordan University of Science and Technology, Irbid, Jordan
    • Cambridge Cancer Center, Cambridge, UK
    • Corresponding Author InformationCorresponding author. P.O. Box 2954, Irbid 21110, Jordan. Tel.: +962-79-543-5379; fax: +962-2-720-0624
    • ,
  • Z.O. Amarin

      Affiliations

    • Department of Obstetrics and Gynecology, Jordan University of Science and Technology, Irbid, Jordan
    • ,
  • J.A. Latimer

      Affiliations

    • Department of Obstetrics and Gynecology, Jordan University of Science and Technology, Irbid, Jordan
    • ,
  • R.A. Crawford

      Affiliations

    • Cambridge Cancer Center, Cambridge, UK

Received 7 August 2003; received in revised form 23 October 2003; accepted 23 October 2003.

Abstract 

Objectives: To assess the ability of a risk malignancy index (RMI) based on serum levels of CA 125, ultrasound findings, and menopausal status to discriminate between benign and malignant pelvic masses in a particular population. Methods: A retrospective study was conducted of 100 women with pelvic masses admitted for laparotomy. The sensitivity and specificity of serum levels of CA 125, ultrasound findings, and menopausal status were calculated both separately and combined into a RMI to diagnose malignancy. Results: The RMI was more accurate than any single criterion in diagnosing malignancy. Using a cut-off level of 200 to indicate malignancy, the RMI gave a sensitivity of 90%, specificity of 89%, positive predictive value of 96%, and negative predictive value of 78%. Conclusion: The RMI is able to correctly discriminate between malignant and benign pelvic masses. It is a simple scoring system that can be introduced easily into clinical practice to facilitate the selection of patients who would benefit from primary surgery.

Keywords:  Risk of malignancy index, CA 125, Menopausal status

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PII: S0020-7292(04)00009-8

doi:10.1016/j.ijgo.2003.10.009

International Journal of Gynecology & Obstetrics
Volume 85, Issue 3 , Pages 255-258, June 2004

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