International Journal of Gynecology & Obstetrics
Volume 88, Issue 3 , Pages 281-285 , March 2005

Low-dose secnidazole in the treatment of bacterial vaginosis

  • J.T. Núñez

      Affiliations

    • Faculty of Medicine, University of Zulia, Hospital Manuel Noruega Trigo, Maracaibo, Venezuela
    • Corresponding Author InformationCorresponding author. Laboratory of Molecular Technology, National Cancer Institute, 915 Tollouse Ave, Suite 211, Frederick, Maryland, 21701, United States. Tel.: +1 301 846 6440; fax: +1 301 846 6100.
    • ,
  • G. Gómez

      Affiliations

    • Hospital Manuel Noriega Trigo, Maracaibo, Venezuela

Received 3 August 2004 ,Revised 16 November 2004 ,Accepted 19 November 2004.

References 

  1. Amsel R, Totten PA, Spiegel CA, Chen KCS, Eschenbach D, Holmes KK. Non-specific vaginitis: diagnostic and microbial and epidemiological associations. Am. J. Med. 1983;74:14–22
  2. Eschenbach DA, Hillier S, Critchlow C, Stevens C, DeRouen T, Holmes KK. Diagnosis and clinical manifestations of bacterial vaginosis. Am. J. Obstet. Gynecol. 1988;158:819–828
  3. Livengood CH, Thomason JL, Hill GB. Bacterial vaginosis: diagnostic and pathogenic findings during topical clindamycin therapy. Am. J. Obstet. Gynecol. 1990;163:515–520
  4. Schwebke JR. Asymptomatic bacterial vaginosis: response to therapy. Am. J. Obstet. Gynecol. 2000;183:1434–1439
  5. Haefner HK. Current evaluation and management of vulvovaginitis. Clin. Obstet. Gynecol. 1999;42:184–195
  6. Hill LH, Ruparelia H, Embil JA. Non specific vaginitis and other genital infections in three clinic populations. Sex. Transm. Dis. 1983;10:114–118
  7. Gravett MG, Nelson HP, DeRouen T, Critchlow CW, Eschenbach DA, Holmes KK. Independent association of bacterial vaginosis and Chlamydia trachomatis infection with adverse pregnancy outcome. JAMA. 1986;256:1899–1903
  8. Soper DE. Bacterial vaginosis and post-operative infections. Am. J. Obstet. Gynecol. 1993;169:467–469
  9. Gravett MG, Hummel D, Eschenbach DA, Holmes KK. Preterm labor associated with subclinical amniotic fluid infection and with bacterial vaginosis. Obstet. Gynecol. 1986;67:229–237
  10. Lamont RF, Taylor-Robinson D, Newman M, Wigglesworth J, Elder MG. Spontaneous early preterm labour associated with abnormal genital bacterial colonization. Br. J. Obstet. Gynaecol. 1986;93:804–810
  11. McGregor J, French J, Seo K. Premature rupture of membranes and bacterial vaginosis. Am. J. Obstet. Gynecol. 1993;169:464–466
  12. Gibbs R. Chorioamnionitis and bacterial vaginosis. Am. J. Obstet. Gynecol. 1993;169:460–462
  13. Watts DH, Krohn MA, Hillier SL, Eschenbach DA. Bacterial vaginosis as a risk factor for post-cesarean endometritis. Obstet. Gynecol. 1990;75:52–58
  14. Centers for Disease Control. Sexually Transmitted Diseases Guidelines. MMWR 2002; 51/RR6:43.
  15. Milani M, Bercellona E, Agnello A. Efficacy of the combination of 2 g oral tinidazole and acidic buffering vaginal gel in comparison with vaginal clindamycin alone in bacterial vaginosis: a randomized, investigator-blind controlled trial. A Eur. J. Obstet., Gynecol., Reprod. Biol. 2003;109:67–71
  16. Mohanty KC, Deighton R. Comparison of 2 g simple dose of metronidazole, nimorazole and tinidazole in the treatment of vaginitis associated with Gardnerella vaginalis. J. Antimicrob. Chemother. 1987;19:393–399
  17. Saraçoğlu F, Gől K, Şahin Ï, Tűrkkani B, Atalay C, Őztopçu C. Treatment of bacterial vaginosis with oral or vaginal ornidazole, secnidazole and metronidazole. Int. J. Obstet. Gynecol. 1998;62:59–61
  18. Gillis JC, Wiseman LR. Secnidazole: a review of its antimicrobial activity, pharmacokinetic properties and therapeutic use in the management of protozoal infections and bacterial vaginosis. Drugs. 1996;5:621–638
  19. Lamp KC, Freeman CD, Klutman NE, Lacy MK. Pharmacokinetics and pharmacodynamics of nitroimidazole antimicrobials. Clin. Pharmacokinet. 1999;36:353–373
  20. Videau D, Niel G, Siboulet A, Catalan F. Secnidazole. A 5-nitroimidazole derivate with a long half-life. Br. J. Vener. Dis. 1978;54:77–80
  21. Spence MR, Harwell TS, Davies MC, Smith JL. The minimum single oral metronidazole dose for treating trichomoniasis: a randomized blinded study. Obstet. Gynecol. 1997;89:699–703
  22. Schwebke JR. Asymptomatic bacterial vaginosis: response to therapy. Am. J. Obstet. Gynaecol. 2000;183:1434–1439

PII: S0020-7292(04)00494-1

doi: 10.1016/j.ijgo.2004.11.028

International Journal of Gynecology & Obstetrics
Volume 88, Issue 3 , Pages 281-285 , March 2005

Article Tools