Volume 88, Issue 3 , Pages 286-291, March 2005
Prognostic significance of DNA quantification by flow cytometry in ovarian tumors
Abstract
Objective
The objective of our study is to evaluate prognostic significance of DNA quantification by flow cytometry in ovarian tumor.
Methods
A prospective analysis was performed on 56 ovarian tumor patients treated in the Yonsei Medical Center from Feb. 2000 to Jan. 2003.
Results
Regarding the association between tumor grade and the DNA quantitative analysis, as tumor grade increased, the quantity of aneuploid cells and S-phase fraction (SPF) increased. In addition, SPF was increased significantly in the advanced staged patients (P=0.04) and SPF was significantly increased in aneuploid tumors (P=0.03). The overall survival rate was poor for patients with aneuploid tumors and for patients with tumors showing over SPF (10%).
Conclusion
Our data demonstrated that the prognosis was poor for patients with aneuploid cancers or increased SPF. Therefore, DNA quantification by flow cytometry may provide important information for predicting the prognosis of the disease.
Keywords: Ovarian tumor, Prognostic factor, DNA ploidy, S-phase fraction, CA-125
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PII: S0020-7292(04)00498-9
doi:10.1016/j.ijgo.2004.12.010
© 2004 International Federation of Gynecology and Obstetrics. Published by Elsevier Inc. All rights reserved.
Volume 88, Issue 3 , Pages 286-291, March 2005
