International Journal of Gynecology & Obstetrics
Volume 88, Issue 3 , Pages 286-291 , March 2005

Prognostic significance of DNA quantification by flow cytometry in ovarian tumors

Received 12 July 2004 ,Revised 12 November 2004 ,Accepted 23 November 2004.

References 

  1. Sigurdsson K, Alm P, Gullberg B. Prognostic factors in malignant epithelial ovarian tumors. Gynecol. Oncol. 1983;15:370–380
  2. Kallioniemi OP, Punnonen R, Mattila J, Lehtinen M, Koivula T. Prognostic significance of DNA index, multiploidy, and S-phase fraction in ovarian cancer. Cancer. 1988;61:334–339
  3. Rustin GJ, Nelstrop AE, Tuxen MK, Lambert HE. Defining progression of ovarian carcinoma during follow-up according to CA-125: a North Thames Ovary Group Study. Ann. Oncol. 1996;7:361–364
  4. Van der Burg ME, Lammes FB, van Putten W, Stoter G. Ovarian cancer: the prognostic value of the serum half-life of CA-125 during induction chemotherapy. Gynecol. Oncol. 1988;30:307–312
  5. Rosen A, Sevelda P, Klein M, Beck A. A CA-125 score as a prognostic index in patients with ovarian cancer. Arch. Gynecol. Obstet. 1990;247:125–129
  6. Mogensen O. Prognostic value of CA-125 in advanced ovarian cancer. Gynecol. Oncol. 1992;44:207–212
  7. Barlogie B, Drewinko B, Schumann J. Cellular DNA content as a marker of neoplasia in man. Am. J. Med. 1980;69:195–203
  8. Garcia RL, Gown AM. Analysis of proliferative grade using anti PCNA/cyclin monoclonal antibodies in formalin fixed, paraffin embedded tissues, comparison with flow cytometric analysis. Am. J. Pathol. 1989;134:733–739
  9. Friedlander ML, Heldey DW, Swanson C. Prediction of long-term survivals by flow cytometric analysis of cellular DNA content in patients with advanced ovarian cancer. J. Clin. Oncol. 1988;6:282–290
  10. Rice LW, Mark SD, Berkowitz RS, Goff BA, Lage JM. Clinicopathologic variables, operative characteristics, and DNA ploidy in predicting outcome in ovarian epithelial carcinoma. Obstet. Gynecol. 1995;86:379–385
  11. Meyer JS, Gorsell DJ, Yim S. Cell proliferation in ovarian carcinoma: superior accuracy of S-phase fraction(SPF) by DNA labeling index versus flow cytometric SPF, lack of independent prognostic power for SPF and DNA ploidy, and limited effect of SPF on tumor growth rate. Gynecol. Oncol. 2001;81:466–476
  12. Rose NR, Marcrio ECD, Fahey JL, Frendman H, Penn GM. In: Manual of clinical laboratory immunology. 5th ed.. ASM; 1997;p. 255–261
  13. Annual Report of the Central Cancer Registry in Korea. Central Cancer Registry Center in Korea. Republic of Korea. Ministry of Health and Welfare; 2003.
  14. Barlogie B, Raber MN, Schumann J. Flow cytometry in clinical cancer research. Cancer Res. 1983;43:3982–3989
  15. Friedlander ML, Hedley DW, Taylor IW, Russel P, Coates AS, Tatersall MHN. Influence of cellular DNA content on survival in advanced ovarian cancer. Cancer. 1984;44:397–400
  16. Strang P, Stendahl U, Sorbe B. Polyclonal cervical tumors detected by flow cytometry. Anticancer Res. 1986;6:171–176
  17. Hansson J, Tribukalt B, Lewensohn R, Ringborg U. Flow cytofluorometric analyses of metastases of human malignant melanomas. Anal. Quant. Cytol. 1982;4:99–104
  18. Merkel DE, McGuire WL. Ploidy, proliferative activity and prognosis: DNA flow cytometry of solid tumors. Cancer. 1990;65:1194–1205
  19. Hedley DW, Friedlander ML, Taylor IW, Rugg CA, Musgrove EA. Method for analysis of cellular DNA content to paraffin embedded pathological material using flow cytometry. J. Histochem. Cytochem. 1983;31:1333–1336
  20. Schutte B, Reyners MM, Bosman FT. Flow cytometric determination of DNA ploidy level in nuclei isolated from paraffin embedded tissue. Cytometry. 1958;6:26–30
  21. Stephenson RA, Gay H, Fair WR, Melamed MR. Effect of section thickness on quality of flow cytometric DNA content determinations in paraffin-embedded tissue. Cytometry. 1986;7:41–44
  22. Jacobsen AB, Fossa SD, Thorud E. DNA flow cytometric values in bladder carcinoma biopsies obtained from fresh and paraffin-embedded material. APMIS. 1988;96:25–29
  23. Deitch AD, White RDV, Madewell BR. False DNA aneuploidy in canine and human neoplasms. Anticancer Res. 1993;13:2117–2118
  24. Nyvang GB, Mogensen O, Bichel P, Jakobsen A. Combined prognostic importance of CA-125, histopathologic grade and DNA index in advanced ovarian cancer. Eur. J. Gynecol. Oncol. 2000;21:569–572

PII: S0020-7292(04)00498-9

doi: 10.1016/j.ijgo.2004.12.010

International Journal of Gynecology & Obstetrics
Volume 88, Issue 3 , Pages 286-291 , March 2005

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