Serum tumor necrosis factor alpha receptors p55/p75 ratio and ovarian cancer detection

Rzymski, P.; Opala, T.; Wilczak, M.; Woźniak, J.; Sajdak, S.

doi:10.1016/j.ijgo.2004.12.015

« Previous Next »International Journal of Gynecology & Obstetrics
Volume 88, Issue 3 , Pages 292-298, March 2005

Serum tumor necrosis factor alpha receptors p55/p75 ratio and ovarian cancer detection

P. Rzymski
- Department of Mother's and Child's Health, Karol-Marcinkowski University of Medical Sciences, Polna St 33, 60-535 Poznan, Poland
- Corresponding author. Tel.: +48 605 393096; fax: +48 61 8419288.
T. Opala
- Department of Mother's and Child's Health, Karol-Marcinkowski University of Medical Sciences, Polna St 33, 60-535 Poznan, Poland
M. Wilczak
- Department of Educational Medicine, Karol-Marcinkowski University of Medical Sciences, Polna St 33, 60-535 Poznan, Poland
J. Woźniak
- Department of Mother's and Child's Health, Karol-Marcinkowski University of Medical Sciences, Polna St 33, 60-535 Poznan, Poland
S. Sajdak
- Department of Gynaecologic Surgery, Karol-Marcinkowski University of Medical Sciences, Polna St 33, 60-535 Poznan, Poland

Received 9 September 2004; received in revised form 9 December 2004; accepted 22 December 2004.

Abstract

Objective

Early ovarian cancer detection is still very difficult and patients are mostly in advanced stages, with obvious influence on poor prognosis.

Method

Fifty-one ovarian cancer patients and 16 healthy controls had the serum concentrations of TNFα receptor p55, p75 and CA-125 measured prospectively and preoperatively.

Result

Mean concentrations of TNFα receptor p55, p75 and CA-125 in patients with ovarian cancer were higher than in controls. The ratios of p55 and p75 receptor in ovarian cancer and controls were 0.73±0.38 and 0.55±0.06 respectively. The areas under ROC curve in detecting malignancy (all FIGO stages) were 0.73, 0.65, 0.88 and 0.85 for p55, p75, p55/p75 ratio and CA-125 respectively. The areas under ROC curve in detecting stage I of ovarian cancer were 0.52, 0.60, 0.84 and 0.66 for p55, p75, p55/p75 ratio and CA-125 respectively.