International Journal of Gynecology & Obstetrics
Volume 93, Issue 2 , Pages 142-143 , May 2006

Maternal folate receptor autoantibodies and cleft lip and/or palate

  • J.B. Bliek

      Affiliations

    • Department of Obstetrics and Gynecology/Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Center, Rotterdam, Nijmegen, The Netherlands
    • ,
  • S.P. Rothenberg

      Affiliations

    • Department of Medicine, State University of New York Downstate Medical Center, Brooklyn, New York, USA
    • ,
  • R.P.M. Steegers-Theunissen

      Affiliations

    • Department of Obstetrics and Gynecology/Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Center, Rotterdam, Nijmegen, The Netherlands
    • Department of Epidemiology and Biostatistics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    • Department of Pediatrics/Division of Pediatric Cardiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    • Department of Clinical Genetics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    • Corresponding Author InformationCorresponding author. Erasmus MC, University Medical Center, Department of Obstetrics and Gynecology, Entreebuilding Room He 1.28, P.O. Box 2040, 3000 CA Rotterdam. Tel.: +31 10 4636886; fax: +31 10 4636815.

Received 2 October 2005 ,Revised 16 January 2006 ,Accepted 17 January 2006.

References 

  1. Van Rooij IALM, Vermeij-Keers C, Kluijtmans LAJ, Ocke MC, Zielhuis GA, Goorhuis-Brouwer SM, et al. Does the interaction between maternal folate intake and the methylenetetrahydrofolate reductase polymorphisms affect cleft lip with or without cleft palate risk. Am J Epidemiol. 2003;157:583–591
  2. DaCosta M, Sequeira JM, Rothenberg SP, Weedon J. Antibodies to folate receptors impair embryogenesis and fetal development in the rat. Birth Defects Res (Part A). 2003;67:837–847
  3. Rothenberg SP, da Costa MP, Sequeira JM, Cracco J, Roberts JL, Weedon J, et al. Autoantibodies against folate receptors in women with a pregnancy complicated by a neural-tube defect. N Engl J Med. 2004;350(2):134–142
  4. Van der Put NMJ, Gabreëls F, Stevens EMB, Smeitink JAM, Trijbels FJM, Eskes TKAB, et al. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural tube defects?. Am J Hum Genet. 1998;62:1044–1051

PII: S0020-7292(06)00029-4

doi: 10.1016/j.ijgo.2006.01.021

International Journal of Gynecology & Obstetrics
Volume 93, Issue 2 , Pages 142-143 , May 2006

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