International Journal of Gynecology & Obstetrics
Volume 93, Issue 2 , Pages 123-129 , May 2006

Expression of CD28 and cytotoxic T lymphocyte antigen 4 at the maternal–fetal interface in women with unexplained pregnancy loss

  • Xipeng Wang

      Affiliations

    • Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China
  • ,
  • Zhengwen Ma

      Affiliations

    • Department of Neurobiology, Shanghai Jiao Tong University, China
  • ,
  • Yan Hong

      Affiliations

    • Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China
  • ,
  • Peihua Lu

      Affiliations

    • Department of Neurobiology, Shanghai Jiao Tong University, China
  • ,
  • Qide Lin

      Affiliations

    • Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China
    • Corresponding Author InformationCorresponding author. Tel.: +86 21 63200506 (Office), +86 21 53070702 (Home); fax: +86 21 63730455.

Received 14 October 2005 ,Revised 24 January 2006 ,Accepted 25 January 2006.

References 

  1. Stephenson MD. Frequency of factors associated with habitual abortion in 197 couples. Fertil Steril. 1996;66:24–29
  2. Cramer DW, Wise L. The epidemiology of recurrent pregnancy loss. Semin Reprod Med. 2000;18:331–339
  3. Tafuri A, Alferink J, Moller P, Hammerling GJ, Arnold B. T cell awareness of paternal alloantigens during pregnancy. Science. 1995;270:630–633
  4. Porter TF, Scott JR. Alloimmune causes of recurrent pregnancy loss. Semin Reprod Med. 2000;18:393–400
  5. Pandey MK, Thakur S, Agrawal S. Lymphocyte immunotherapy and its probable mechanism in the maintenance of pregnancy in women with recurrent spontaneous abortion. Arch Gynecol Obstet. 2004;269:161–172
  6. Bocko D, Kosmaczewska A, Ciszak L, Teodorowska R, Frydecka I. CD28 costimulatory molecule—expression, structure and function. Arch Immunol Ther Exp (Warsz). 2002;50:169–177
  7. Linsley PS, Greene JL, Brady W, Bajorath J, Ledbetter JA, Peach R. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity. 1994;1:793–801
  8. Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G, et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature. 2003;423:506–511
  9. Ligers A, Teleshova N, Masterman T, Huang WX, Hillert J. CTLA-4 gene expression is influenced by promoter and exon 1 polymorphisms. Genes Immun. 2001;2:145–152
  10. Wang X, Lin Q, Ma Z, Hong Y, Zhao A, Di W, et al. Association of the A/G polymorphism at position 49 in exon 1 of CTLA-4 with the susceptibility to unexplained recurrent spontaneous abortion in the Chinese population. Am J Reprod Immunol. 2005;53:100–105
  11. Rezvany MR, Jeddi-Tehrani M, Wigzell H, Osterborg A, Mellstedt H. Leukemia-associated monoclonal and oligoclonal TCR-BV use in patients with B-cell chronic lymphocytic leukemia. Blood. 2003;101:1063–1070
  12. Mellor AL, Munn DH. Immunology at the maternal–fetal interface: lessons for T cell tolerance and suppression. Annu Rev Immunol. 2000;18:367–391
  13. Moffett A, Loke YW. The immunological paradox of pregnancy: a reappraisal. Placenta. 2004;25:1–8
  14. Sayegh M, Akalin E, Hancock W, Russell M, Carpenter C, Linsley P, et al. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J Exp Med. 1995;181:1869–1874
  15. Lin H, Mosmann TR, Guilbert L, Tuntipopipat S, Wegmann TG. Synthesis of T helper 2-type cytokines at the maternal–fetal interface. J Immunol. 1993;151:4562–4573
  16. Wang X, Ma Z, Hong Y, Zhao A, Lu PH, Lin Q. The skewed TCR BV repertoire displayed at the maternal–fetal interface of women with unexplained pregnancy loss. Am J Reprod Immunol. 2005;54:84–95
  17. Zhu XY, Zhou YH, Wang MY, Jin LP, Yuan MM, L. DJ. Blockade of CD86 signaling facilitates a Th2 bias at the maternal–fetal interface and expands peripheral CD4+CD25+ regulatory T cells to rescue abortion-prone fetuses. Biol Reprod. 2005;72:338–345
  18. Ruter J, Hoffmann T, Heiser U, Demuth HU, Arck PC, Klapp BF, et al. The expression of T-cell surface antigens CTLA-4, CD26, and CD28 is modulated by inhibition of dipeptidylpeptidase IV (DPP IV, CD26) activity in murine stress-induced abortions. Cell Immunol. 2002;220:150–156
  19. Tanaka T, Duke-Cohan JS, Kameoka J, Yaron A, Lee I, Schlossman SF, et al. Enhancement of antigen-induced T-cell proliferation by soluble CD26/dipeptidyl peptidase IV. Proc Natl Acad Sci U S A. 1994;91:3082–3086
  20. Lenschow DJ, Ho SC, Sattar H, Rhee L, Gray G, Nabavi N, et al. Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J Exp Med. 1995;181:1145–1155
  21. Quenby S, Bates M, Doig T, Brewster J, Lewis-Jones DI, Johnson PM, et al. Pre-implantation endometrial leukocytes in women with recurrent miscarriage. Hum Reprod. 1999;14:2386–2391
  22. Yahata T, Kurabayashi T, Honda A, Takakuwa K, Tanaka K, Abo T. Decrease in the proportion of granulated CD56+ T-cells in patients with a history of recurrent abortion. J Reprod Immunol. 1998;38:63–73
  23. Murata K, Dalakas MC. Expression of the co-stimulatory molecule BB-1, the ligands CTLA-4 and CD28 and their mRNAs in chronic inflammatory demyelinating polyneuropathy. Brain. 2000;123(Pt 8):1660–1666

PII: S0020-7292(06)00056-7

doi: 10.1016/j.ijgo.2006.01.027

International Journal of Gynecology & Obstetrics
Volume 93, Issue 2 , Pages 123-129 , May 2006