International Journal of Gynecology & Obstetrics
Volume 99, Supplement 2 , Pages S202-S205, December 2007

Treatment of postpartum hemorrhage with misoprostol

  • J. Blum

      Affiliations

    • Gynuity Health Projects, New York, NY, USA
    • Corresponding Author InformationCorresponding author. Gynuity Health Projects, 15 East 26th Street, Suite 1617New York, NY 10010USA. Tel: 212-448-1230 Fax: 212-448-1260.
  • ,
  • Z. Alfirevic

      Affiliations

    • School of Reproductive and Developmental Medicine, University of Liverpool, Liverpool, UK
  • ,
  • G. Walraven

      Affiliations

    • Secretariat de Son Altesse l'Aga Khan, Aiglemont, France
  • ,
  • A. Weeks

      Affiliations

    • School of Reproductive and Developmental Medicine, University of Liverpool, Liverpool, UK
  • ,
  • B. Winikoff

      Affiliations

    • Gynuity Health Projects, New York, NY, USA

published online 04 October 2007.

Recommended Dosage

Oral misoprostol 600 μg as a single dose

Abstract 

A literature review was conducted to determine whether misoprostol is an effective treatment for postpartum hemorrhage (PPH) and in what dose. All English language articles published before March 2007 reporting on misoprostol for treatment of PPH were reviewed. Unpublished data previously presented at international scientific meetings were also included in the review. Little evidence exists in support of misoprostol for treatment of postpartum hemorrhage (PPH). Nonetheless, PPH remains a major killer of women worldwide, and new treatment options are widely sought. For this reason, we recommend a single dose of misoprostol 600 μg oral or sublingual for PPH treatment in instances when other treatments have either failed to work or are not available.

Keywords: Misoprostol, Postpartum hemorrhage

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PII: S0020-7292(07)00516-4

doi:10.1016/j.ijgo.2007.09.013

International Journal of Gynecology & Obstetrics
Volume 99, Supplement 2 , Pages S202-S205, December 2007