International Journal of Gynecology & Obstetrics
Volume 102, Issue 2 , Pages 141-145, August 2008

Additional antibiotic use and preterm birth among bacteriuric and nonbacteriuric pregnant women☆

  • Brenna L. Anderson

      Affiliations

    • Department of Obstetrics and Gynecology, Brown University, Providence, Rhode Island, USA
    • Corresponding Author InformationCorresponding author. Division of Maternal Fetal Medicine, Women and Infant's Hospital/Brown University, 101 Dudley Street 3rd floor, Providence, RI 02905, USA. Tel.: +1 401 274 1122x2362; fax: +1 401 453 7622.
    • ,
  • Hyagriv N. Simhan

      Affiliations

    • Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    • ,
  • Kathryn Simons

      Affiliations

    • Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    • ,
  • Harold C. Wiesenfeld

      Affiliations

    • Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Received 5 March 2008; received in revised form 8 April 2008; accepted 9 April 2008. published online 12 May 2008.

Abstract 

Objective: To determine the risk of preterm birth related to use of additional antibiotics.

Methods: Women with Group B streptococcal (GBS) bacteriuria and women with negative urine cultures in a hospital-wide research registry were included. The impact of prenatal antibiotics in addition to those used to treat GBS bacteriuria was assessed. Logistic regression was used to determine the risk of preterm birth among bacteriuric women who received “other antibiotics”.

Results: A total of 203 women with GBS bacteriuria and 220 women with negative cultures were included. The frequency of preterm birth was 16% (35/220) for women in the control group, 16% (19/120) for women with bacteriuria not receiving additional antibiotics, and 28% (23/83) for women with bacteriuria who received antibiotics for “other indications”. Among women with GBS bacteriuria, the risk of preterm birth was increased with the use of “other antibiotics” (adjusted odds ratio, 2.7; 95% confidence interval, 1.2–6.1).

Conclusion: Among women with GBS bacteriuria, exposure to additional antibiotics is associated with an increased risk of preterm birth.

Keywords: Antibiotics, Bacteriuria, Group B streptococcus, Pregnancy, Preterm birth

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☆ Poster presented at the 27th Annual Meeting of the Society for Maternal-Fetal Medicine, 5–10 February 2007, San Francisco, CA, USA.

PII: S0020-7292(08)00161-6

doi:10.1016/j.ijgo.2008.04.005

International Journal of Gynecology & Obstetrics
Volume 102, Issue 2 , Pages 141-145, August 2008

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