Aggressive characteristics of cervical cancer in young women in Taiwan

Lau, Hei-Yu; Juang, Chi-Mou; Chen, Yi-Jen; Twu, Nae-Fang; Yen, Ming-Shyen; Chao, Kuan-Chong

doi:10.1016/j.ijgo.2009.07.029

« Previous Next »International Journal of Gynecology & Obstetrics
Volume 107, Issue 3 , Pages 220-223, December 2009

Aggressive characteristics of cervical cancer in young women in Taiwan

Hei-Yu Lau
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan
Chi-Mou Juang
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan
- Institute of Public Health, National Yang-Ming University, Taipei, Taiwan
Yi-Jen Chen
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan
Nae-Fang Twu
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan
Ming-Shyen Yen
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan
Kuan-Chong Chao
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan
- Corresponding author. Department of Gynecology and Obstetrics, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan. Tel.: +886 2 28735423; fax: +886 2 28734101.

Received 6 May 2009; received in revised form 5 June 2009; accepted 20 July 2009. published online 28 August 2009.

Abstract

Objective

To compare the characteristics and prognosis of cervical cancer in young women (under 30 years) with those of older women (over 30 years).

Methods

A retrospective study of 2443 patients diagnosed with FIGO stage IA–IIA cervical cancer who underwent surgical procedures between January 1983 and December 2007.

Results

Thirty patients (1.2%) were 30 years or younger. The proportion of non-squamous cell carcinoma was higher in patients 30 years or younger compared with in patients over 30 years (14/30, 46.7% vs 10/30, 33.3%; P=0.001). A higher rate of parametrial involvement was found in the younger group of patients compared with those over 30 years (10/30, 33.3% vs 289/2413, 12.0%; P=0.001). Patients under 30 years had a higher rate of distant metastases compared with older patients (60% vs 49.7%; P=0.036).

Conclusions

Non-squamous histology, parametrial involvement, a higher rate of distant metastases, and poorer prognosis are more common in women aged 30 or younger with cervical cancer than in older women with the disease.

Keywords: Cervical adenocarcinoma, Cervical cancer, Non-squamous cell carcinoma, Young women