Primary squamous cell carcinoma of the ovary associated with endometriosis
Received 3 June 2009; received in revised form 31 July 2009; accepted 1 September 2009. published online 28 September 2009.
Abstract
Objective
To analyze the clinical, therapeutic, and pathologic features of published cases presenting primary squamous cell carcinoma (SCC) of the ovary associated with endometriosis.
Methods
A case report, 15 cases of infiltrating SCC of the ovary associated with or arising from endometriosis, and 1 case of synchronous carcinoma in situ in the cervix and ovary from a review of the literature were studied.
Results
Young age, advanced stage of the disease, and hypogastric pain were frequent at the time of diagnosis. There was no ascites, but infiltration of neighboring organs was common. The tumor was associated with 80% patient mortality in the first few months. Adjuvant chemotherapy with paclitaxel and carboplatin or cisplatin appeared to improve the results.
Conclusion
Primary SCC of the ovary associated with endometriosis is extremely rare and has a poor prognosis. The best therapeutic results are obtained with paclitaxel and carboplatin or cisplatin after radical surgery.
aDepartment of Obstetrics and Gynecology, San Juan University Hospital, Alicante, Spain
bDepartment of Pathology, San Juan University Hospital, Alicante, Spain
cDepartment of Surgical Pathology, San Juan University Hospital, Alicante, Spain
dDepartment of Medical Oncology, San Juan University Hospital, Alicante, Spain
eDepartment of Gynecology, Miguel Hernandez University, Campus of San Juan, Alicante, Spain
Corresponding author. Departamento/División de Ginecología, Facultad de Medicina de la Universidad Miguel Hernández, Campus de San Juan, 03550 Alicante, Spain. Tel.: +34 965919385; fax: +34 965919550.
ABSTRACT