Risk factors for unexplained recurrent spontaneous abortion in a population from southern China
Received 18 June 2009; received in revised form 21 August 2009; accepted 13 October 2009. published online 09 November 2009.
Abstract
Objective
To determine risk factors for recurrent spontaneous abortion (RSA) in women from southern China.
Method
We looked for associations between RSA and body mass index (BMI), family history of spontaneous abortion, smoking, exposure to environmental tobacco smoke (ETS [also known as passive smoking]), and alcohol and coffee consumption using an unconditional logistic regression model involving 326 patients with RSA and 400 controls.
Results
Whereas smoking, alcohol consumption, and coffee consumption were not associated with increased risk of RSA, both short (<1hour/day) and long (≥1hour/day) periods of ETS were associated (adjusted odds ratio [OR], 2.30; 95% confidence interval [CI], 1.50–3.52 and adjusted OR, 4.75; 95% CI, 3.23–6.99, respectively). The increased risk of RSA was significant for participants with a BMI of 24.0 or greater (adjusted OR, 1.54; 95% CI, 1.12–2.14) and those with a family history of miscarriage (adjusted OR, 2.12; 95% CI, 1.28–3.49).
Conclusion
We found ETS, a higher BMI, and a family history of RSA to be independent risk factors for RSA in our population.
aObstetrics and Gynecology Department of Women and Children’s Care Hospital of Guangdong Province, Guangzhou City, China
bDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of GuangZhou Medical College, Guangzhou City, China
cFamily planning Research Institute of Guangdong Province, Guangzhou City, China
dDepartment of Obstetrics and Gynecology Research Institute, the first affiliated hospital of Jinan University, Guangzhou City, China
Corresponding author. Department of Obstetrics and Gynecology Research Institute, The First Affiliated Hospital of Jinan University, Guangzhou City, China, Huangpu Road 26, Guangzhou 510632, P.R. China. Tel.: +86 20 89033789.
ABSTRACT