International Journal of Gynecology & Obstetrics
Volume 109, Issue 3 , Pages 239-241, June 2010

Insulin resistance, dyslipidemia, and metabolic syndrome in women with polycystic ovary syndrome

  • Akmal El-Mazny

      Affiliations

    • Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Egypt
    • ,
  • Nermeen Abou-Salem

      Affiliations

    • Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Egypt
    • ,
  • Walid El-Sherbiny

      Affiliations

    • Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Egypt
    • Corresponding Author InformationCorresponding author. Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, 1 Kasr El-Aini Street, Cairo, Egypt. Tel.: + 20 127498788.
    • ,
  • Ahmed El-Mazny

      Affiliations

    • Department of Internal Medicine, Faculty of Medicine, Cairo University, Egypt

Received 12 December 2009; received in revised form 12 January 2010; accepted 29 January 2010. published online 03 March 2010.

Abstract 

Objective

To investigate the association of insulin resistance with dyslipidemia and metabolic syndrome (MBS) in women with polycystic ovary syndrome (PCOS).

Methods

Fasting glucose (G), insulin (I), and lipid levels were measured in 50 infertile women with PCOS. A fasting G/I ratio of 4.5 or less (n=29) defined insulin resistance (IR).

Results

The mean levels of total cholesterol (P<0.001), low-density lipoprotein (P=0.02), and triglycerides (P<0.001) were significantly higher and the mean levels of high-density lipoprotein were significantly lower (P<0.001) in the IR group. The prevalence of MBS (P=0.02) and obesity (P=0.04), hypertension (P=0.02), fasting hyperglycemia (P=0.03), low high-density lipoprotein levels (P=0.02), and hypertriglyceridemia (P=0.02) were also significantly higher in the IR group.

Conclusion

Insulin resistance is associated with dyslipidemia and MBS in women with PCOS. Lifestyle modification and insulin-sensitizing agents should be part of the management plan.

Keywords: Dyslipidemia, Insulin resistance, Metabolic syndrome, Polycystic ovary syndrome

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PII: S0020-7292(10)00058-5

doi:10.1016/j.ijgo.2010.01.014

International Journal of Gynecology & Obstetrics
Volume 109, Issue 3 , Pages 239-241, June 2010

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