Ovarian response to gonadotropins after laparoscopic salpingectomy for ectopic pregnancy

Xi, Wenyan; Gong, Fei; Tang, Yi; Zhang, Hong; Lu, Guangxiu

doi:10.1016/j.ijgo.2011.10.009

Next »International Journal of Gynecology & Obstetrics
Volume 116, Issue 2 , Pages 93-96, February 2012

Ovarian response to gonadotropins after laparoscopic salpingectomy for ectopic pregnancy

Wenyan Xi
- Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha, China
Fei Gong
- Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha, China
- Reproductive and Genetics Hospital of CITIC–Xiangya, Changsha, China
Yi Tang
- Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha, China
- Reproductive and Genetics Hospital of CITIC–Xiangya, Changsha, China
Hong Zhang
- Reproductive and Genetics Hospital of CITIC–Xiangya, Changsha, China
Guangxiu Lu
- Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha, China
- Reproductive and Genetics Hospital of CITIC–Xiangya, Changsha, China
- Corresponding author at: Central South University, Changsha 410008, China. Tel.: +86 15874281982; fax: +86 7314497661.

Received 5 May 2011; received in revised form 28 August 2011; accepted 19 October 2011. published online 21 November 2011.

Abstract

Objective

To evaluate whether laparoscopic salpingectomy compromises ovarian response in women undergoing controlled ovarian hyperstimulation in vitro fertilization (IVF).

Methods

In a retrospective study in Changsha, China, data from 76 women who underwent ovarian stimulation before and after laparoscopic salpingectomy for ectopic pregnancy were compared with those from 80 women who underwent 2 IVF cycles without surgical intervention between 2004 and 2009.

Results

There were no differences in basal serum follicle-stimulating hormone (FSH) or estradiol (E₂); length of stimulation; or numbers of follicles, retrieved and fertilized oocytes, or high-quality embryos between the cycles before and after salpingectomy; however, initial and total doses of gonadotropins were significantly increased after surgery (P<0.05). IVF parameters were also comparable between the 2cycles among women without surgical intervention, except for a significant increase in initial and total doses of gonadotropins at the second cycle (P<0.05). IVF parameters did not differ between the cycle subsequent to salpingectomy and the second cycle in women without surgical intervention. There were no significant differences between patients with unilateral and those with bilateral salpingectomy, nor between the operated and non-operated ovary in the same individual.